Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Recorded on 05/16/2020. (#35851)