Genomics is a disruptive technology that enables personalized cancer therapy, while suggesting that old paradigms of clinical research and practice cannot work and must be changed. Razelle Kurzrock of the Moores Cancer Center shows how the impact of personalized cancer medicine is likely to be transformative—if the ethical, logistical, and technological challenges are addressed and overcome. Kurzrock is presented as part of the UC San Diego Founders Symposium 2014. Recorded on 11/13/2014. (#29033)