How can we select the best therapies for patients and improve their outcome? A central question in Precision Medicine is which factors determine health and disease in a patient. For most diseases, both environmental and genetic factors play a role. Dr. Melissa Paoloni and Postdoctoral Fellow Martin Kampmann discuss mechanisms by which genes influence disease risk and the response of an individual patient to therapy. The discussion continues on the clinical application of the understanding of genetics and other biology advancements with emphasis on innovative biomarker driven clinical trials in cancer. (#25928)